The cees dekker Diaries
The cees dekker Diaries
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Utilizing one-molecule optical and AFM imaging and pressure-spectroscopy tactics, we look for to unravel the mechanistic aspects of the framework and dynamics of chromosomes. Our investigation interests involve:
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The subsequent articles are merged in Scholar. Their mixed citations are counted only for the initial report.
2007, initial authentic-time detection of strand exchange in homologous recombination by RecA; discovery of the reduced persistence size of finishes of microtubules; and resolved the mechanism of biosensing with carbon nanotubes
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The coiled-coil of your human Rad50 DNA mend protein includes specific segments of amplified flexibility
Due to the fact 2000 he moved to single-molecule biophysics and nanobiology, with exploration from DNA supercoiling research of nucleosomes and DNA maintenance proteins to DNA translocation by means of nanopores. Recently his analysis has centered on studying mobile division with microbes on chip, although his top interest is while in the direction of knowing synthetic cells.
Atomic drive microscopy reveals that vaccinia topoisomerase IB generates filaments on DNA in a cooperative manner
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Right now, we also recognized that it should be doable to utilize one semiconducting carbon nanotube to create a transistor — and we established out to really make it. We stretched personal semiconducting nanotubes throughout metallic electrodes and used the underlying silicon substrate like a gate electrode, developing the basic three-terminal format of the area-result transistor (Fig.
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial mobile division
2006, initial demonstration of molecular sorting in the lab with a chip utilizing ceesdekker.net biomotors; discovery of nanobubbles in reliable-point out nanopores; and first estimate of electrokinetic Vitality conversion in a very nanofluidic channel
2005, discovery from the system of DNA uncoiling by topoisomerase enzymes; discovery of extensive-assortment conformational changes in Mre11/DNA fix complexes; and to start with force measurements over a DNA molecule inside of a nanopore
Lastly, I will briefly sketch a few of our Tips to investigate the constructing of artificial cells, exclusively our initially techniques to determine artificial mobile division.